Suspensions
We develop suspensions prioritizing uniformity, stability, and scalable processes that ensure redispersion.
Uniform dose delivery
Stable suspension performance
Suspension drug products require control of physical stability, redispersibility, and dose uniformity throughout development and manufacturing. Groupe PARIMA develops and manufactures non-sterile oral, nasal, otic, and topical suspensions using scalable processes and disciplined formulation control to support consistent product performance from development through commercial manufacturing.
Consistent Performance at Scale
Robust suspension performance depends on controlling the formulation and process variables that influence physical stability and dose uniformity. We combine formulation development, analytical support, and process understanding to support reproducible performance from development through commercial manufacturing.
DOSE UNIFORMITY YOU CAN TRUST
We control particle characteristics, dispersion, and critical process parameters to maintain dose uniformity as batch size increases.
PHYSICAL STABILITY AND REDISPERSIBILITY
We address settling, aggregation, and redispersibility during formulation development and stability studies to support consistent performance throughout shelf life.
PACKAGING FOR CONSISTENT DELIVERY
We evaluate product–packaging compatibility and delivery requirements to support product stability, dose consistency, and appropriate use.
Reliable product behavior
We design suspension products around particle behavior, reproducible processing, and fit-for-purpose testing so dose uniformity and stability remain predictable.
SET TARGET PARTICLE BEHAVIOR
We define the particle size intent and performance targets that will drive homogeneity, uniformity, dosing consistency, and overall suspension performance.
ENGINEER DISPERSION AND RHEOLOGY
We select and tune excipients and process conditions to maintain even particle distribution, balancing viscosity and handling to keep manufacturing and use practical.
PROVEN REDISPERSION AND DOSE UNIFORMITY
We confirm that the product stays dose-consistent over time, and redispersibility with testing designed to reflect real use and real shelf-life conditions.
DEFINE A REPRODUCIBLE SCALE-UP PROCESS
We translate the formulation into a scalable manufacturing process by identifying and controlling the parameters most affected by batch size, supported by in-house analytical and microbiological testing.
ASSESS PACKAGING AND DELIVERY FIT
We evaluate packaging and delivery early, including options that support consistent dosing and stability during storage, shipping, and routine handling.
Our Capabilities
We design suspension programs around particle behavior, dose uniformity, and packaging fit from the start.
Otic Suspensions
Support localized delivery with dependable dosing. We fine-tune formulation and processing to keep particle distribution consistent, confirm packaging fit early, and support microbial control.
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Establishing the particle size range to support consistent dispersion and reliable delivery in the ear.
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Selecting excipients that support residence time, patient comfort, and preservative compatibility.
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Supporting consistent dosing through early packaging and delivery-fit evaluation, with shake-before-use verification when applicable.
Nasal Suspensions
Offer a strong pathway when a solution is not the best fit. We focus on consistent dosing through the device, including spray performance checks and formulation choices that support stability and microbial integrity.
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Establishing the particle size range to support targeted deposition and consistent spray delivery.
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Selecting excipients that support mucosal retention, comfortable delivery, and preservative compatibility.
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Confirming dose uniformity through device-focused checks, including shake-before-use verification and spray pattern testing.
Topical Suspensions
Perform best when formulation and packaging work as one system. We confirm delivery-fit early, from applicators to agitation-assisted bottles, supporting consistent dosing, stable performance, and a smooth user experience.
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Maintain physical stability of APIs that tend to aggregate or crystallize.
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Ensure even distribution of active particles throughout the product.
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Select and test film-forming agents, emollients, or penetration enhancers as needed.
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Evaluate in vitro release and particle mobility to optimize drug delivery performance.
Oral Suspensions
Well-suited for pediatric, geriatric, and dose-titration programs where flexible administration is important. We establish viscosity and density so the product pours smoothly and maintains consistent performance over shelf life.
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Optimize particle size to improve sedimentation behavior and enhance bioavailability.
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Select and tailor suspending agents (cellulose derivatives, gums, clays) to ensure redispersibility and dose uniformity.
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Engineer palatability solutions through advanced, multi-layered taste-masking strategies.
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Validate preservative efficacy in aqueous, multi-dose formulations to ensure microbial stability.
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Execute ICH-compliant stability studies, including shake tests and sedimentation kinetics, to confirm long-term product performance.
Our Services
We connect development, analytical support, and GMP execution to ensure suspension uniformity and physical stability.
Product Development
Manufacturing-ready development that reduces rework later, with decisions that scale as requirements increase.
Analytical Services
Clear data for decision-making stability plans, and confident release as your program progresses.
Manufacturing & Packaging
Consistent execution designed for predictable release and routine supply, with controlled changes over time.
We make suspension dosing predictable through early control of particle behavior and confirmed stability over time.
Resources
Access practical content to help you plan suspension development and manufacturing with clarity.