Liquids

We develop and manufacture liquid products by focusing on stable performance and reliable dose delivery.

liquids-banner
NON-STERILE LIQUID DOSAGE FORMS

Liquids that scale consistently

Non-sterile liquid drug products require control of formulation stability, dose delivery, and packaging compatibility from development through manufacturing. Groupe PARIMA supports oral, topical, nasal, sublingual, and otic liquids by integrating formulation development, packaging or device selection, and GMP manufacturing to support consistent performance at scale.

Robust formula over shelf life

We integrate formulation development, in-house analytical capabilities, and manufacturing expertise to address the stability, solubility, and performance requirements of non-sterile liquid drug products. 

Proven stability expertise

We build formulations for consistent performance, including solutions, emulsions, and oil‑based formats.

MICROBIOLOGICAL CONTROL

We design preservative strategies supporting non‑sterile liquids across routes of administration.

PACKAGING AND DEVICE FIT 

Align packaging components with formulation to support consistent dose delivery and user experience.

Reliable performance outcomes

We develop non-sterile liquid drug products, supported by fit-for-purpose testing to ensure consistent performance from development through scale-up.

DEFINE THE TARGET PRESENTATION

Translate the target product profile into clear requirements for route of administration, dosing approach, and user experience, then set the CQAs.

DESIGN THE FORMULATION STRATEGY

Select the right formulation, such as solution, emulsion, or oil, based on the solubility approach, excipient compatibility, and sensory profile. 

PRESERVATIVE STRATEGY

Develop a preservative strategy and supporting studies, including preservative efficacy testing when applicable.

CONFIRM PACKAGING AND DEVICE FIT

Align packaging components with formulation properties to support consistent dose delivery and practical use. 

STANDARDIZE GMP EXECUTION

Establish a reproducible manufacturing process with in-house analytical support and an ICH-aligned stability plan.

Our Capabilities

We support liquid products with capabilities built around stable performance, reliable dose delivery, and scale-ready execution.

oral liquids-
Oral Liquids

Support flexible dosing and patient-friendly administration through solutions and emulsions designed for stable performance, practical use, and real-world application.

  • Co-solvents, pH adjustment, or complexation aligned to the API and target profile.
  • Sweeteners, flavor systems, and bitter blockers when relevant to the product.
  • Preservative systems selected to support microbiological control and product acceptability.
nasal liquid
Nasal Liquids

Stable formulation performance and consistent delivery are achieved by aligning formulation, preservation strategy, and device fit to support reliable use.

  • Formulation mucoadhesion adjusted to support mucosal retention and user comfort, where applicable.
  • Approach designed to support uniform delivery across packaging design.
  • Metered-dose or non-metered packaging selected to match formulation and packaging design.
sublingual
Sublingual Liquids

Sublingual liquids require controlled delivery and packaging that supports consistent use. We align formulation with device compatibility to ensure reliable dosing and administration.

  • Pump or spray systems aligned to formulation properties and dosing goals.
  • Formulation and process choices focused on sensorial feel and uniform delivery across actuations.
  • Preservative excipient and testing approach aligned to non-sterile requirements, including PET when applicable.
otic liquid
Otic Liquids

Require stable formulation performance and consistent delivery through the chosen presentation. We align formulation, preservation strategy, and device fit to support reliable use.

  • Robust preservative selection and microbial control aligned to non-sterile otic use, including PET when applicable.
  • Dropper or pump selection aligned to consistent dosing expectations.
  • Excipients and formulation choices tuned to support comfortable, practical use.
topical liquids
Topical Liquids

Dermatologic and mucosal applications require spreadability and cosmetic acceptability. We balance performance and usability through formulation aligned with the application.

  • Excipient selection aligned to absorption goals and skin compatibility.
  • Alcohol-free and non-irritant systems developed when appropriate for sensitive sites.
  • Residue, drying time, and stability assessed under expected usage conditions.
oil-based liquid
Oil-Based Liquids

Lipophilic APIs are well-suited to oil-based systems that support the delivery profile. We optimize oil selection and packaging to ensure stable performance and practical dosing.

  • Dropper bottles or soft tubes selected to support practical, controlled dosing.
  • Preservation approach aligned to the system’s composition and intended use.
  • Mineral and vegetable oil, medium-chain triglycerides, or ester-based blends selected to support stability and API compatibility.

We make liquid performance predictable by aligning stability, preservation, and presentation fit from the start.

Resources

Explore content that helps plan non-sterile liquid drug products with clarity, from formulation strategy to scale-up execution.

White papers
2026/07/06
How Drug Product Formulation Works: Topical, Oral, and Nasal Liquid and Semi-Solid Dosage Forms
White papers
2026/07/03
How Early API Characterization Can Reduce Formulation and Scale-up Risks
Blog
2026/07/03
Topical 101: A Guide to Complex Dermatology Formulation Development
White papers
2026/07/06
How Drug Product Formulation Works: Topical, Oral, and Nasal Liquid and Semi-Solid Dosage Forms
White papers
2026/07/03
How Early API Characterization Can Reduce Formulation and Scale-up Risks
Blog
2026/07/03
Topical 101: A Guide to Complex Dermatology Formulation Development

Contact Us

Develop liquids with confidence.

Share your route of administration, and we help you align formulation, preservation, and packaging to ensure consistent performance at scale.