We develop both oil-in-water and water-in-oil emulsions, depending on the therapeutic and sensory requirements, supporting pharmaceutical companies in resolving common challenges such as:

• Emulsion stability under temperature cycling.
• Homogeneous distribution of poorly soluble APIs.
• Optimization of pH and preservative systems for microbial protection.

The cream formulations we work with are typically manufactured using high-shear homogenization and validated for viscosity, droplet size, and phase stability across the product’s shelf life.

Lotions require precise tuning of flow properties and emulsion stability, which is why our product development services team works, focusing on:

• Enhancing spreadability without compromising API stability. 
• Selecting non-irritant emulsifiers and humectants for sensitive applications.
• Ensuring physical stability and microbial robustness in low-viscosity systems.

We adapt mixing speeds, shear forces, and cooling profiles to maintain uniformity at scale.

Ointments demand control over API solubilization or dispersion, melting behavior, and texture. Our project managers and scientists work directly with clients to:

• Choose the right oleaginous or absorption base. 
• Resolve issues with API sedimentation or crystallization. 
• Minimize grittiness and ensure consistent texture and application profile. 

We also test occlusivity and drug retention using in vitro permeation methods as needed.

Developing gels demands precise control over polymer concentration, pH, and ionic interactions, factors our team expertly manages throughout the formulation process by:

• Selecting optimal gelling agents (carbomers, cellulose derivatives, poloxamers) based on viscosity and drug release needs. 
• Resolving API-polymer interactions that may impact clarity or stability.
• Ensuring batch-to-batch rheological consistency using detailed viscosity and texture analysis. 

We also offer in vitro testing (IVRT) capabilities to support formulation optimization.

We assist in the development of aerosol and mechanical pump foams, helping clients:

• Select appropriate propellants or surfactants to ensure a stable foam structure. 
• Validate actuation and dosing performance over the drug product’s shelf life. 
• Integrate formulation and device design for consistent delivery. 

We also test foam expansion, stability, and collapse time using customized protocols to simulate real use..

Clients consistently turn to us when developing age-adapted formulations or when the physicochemical properties of the API challenge reliable oral delivery. In these cases, our work typically involves:

• Solubility enhancement using co-solvents, pH adjustment, or complexation techniques. 
• Development of taste-masked formulations with sweeteners, flavor systems, and bitter blockers. 
• Optimization of preservative systems to ensure microbial control without compromising organoleptics. 
• Design of emulsion systems when APIs are lipophilic and need uniform dispersion in water-based matrices. 

We enable dose flexibility, a critical requirement in early-phase development and orphan drug applications where precise titration is essential.

While many CDMOs restrict nasal and otic liquid dosage forms to sterile development, Groupe PARIMA offers validated non-sterile alternatives for local delivery applications. We can support your products in both metered-dose and non-metered-dose pumps. We advance the development of aqueous and oil-based nasal and sublingual sprays, and otic drops by implementing robust preservative systems and proven microbial control strategies, in addition to:

• Optimizing viscosity to improve mucosal retention and user comfort 
• Ensuring uniformity of dose delivery across device actuations 
• Selecting droppers or pump systems that prevent contamination and ensure dose accuracy 

All our formulations are designed to comply with regulatory requirements for non-sterile nasal, sublingual, and otic dosage forms, including preservative efficacy testing (PET).

These formulations are typically used for dermatologic, mucosal, or wound care indications. Its development requires a strong balance between API efficacy, spreadability, and cosmetic acceptability, which we’re experts in. We assist clients in formulating solutions or emulsions for spray or drop application by: 

• Choosing excipients that promote absorption while maintaining skin compatibility. 
• Developing alcohol-free, non-irritant systems when needed for sensitive sites. 
• Evaluating residue, drying time, and stability under usage conditions. 

Oil-based liquids are particularly well-suited for lipophilic APIs and delivering moisturizing or occlusive effects in topical and otic applications.

Our team brings deep expertise in selecting and optimizing oil blends (mineral, vegetable, ester-based) to ensure drug formulation stability, enhance penetration, and maintain API compatibility by:

• Designing easy-to-dose systems, including dropper bottles or soft tubes. 
• Ensuring appropriate preservation, even in low-water-content systems. 

We also address challenges such as API sedimentation and layer separation through excipient engineering and process optimization.

Oral suspension dosages are essential in pediatric, geriatric, and dose-adjustable therapies, where solid oral dosage forms are often impractical or poorly tolerated. Our collaboration with your team typically includes:

• Optimizing particle size to improve sedimentation behavior and enhance bioavailability.
• Selecting and tailoring suspending agents (cellulose derivatives, gums, clays) to ensure redispersibility and dose uniformity.
• Engineering palatability solutions through advanced, multi-layered taste-masking strategies.
• Validating preservative efficacy in aqueous, multi-dose formulations to ensure microbial stability.
• Executing ICH-compliant stability studies, including shake tests and sedimentation kinetics, to confirm long-term product performance.

We tailor viscosity and density to balance ease of pouring with suspension stability throughout the drug product’s shelf life.

For APIs with limited solubility or where targeted deposition is required, suspensions provide a scientifically sound alternative to solution-based formulations. Here is how we work together:

• Engineering the correct particle size to avoid clogging and to achieve optimal distribution on mucosal surfaces. 
• Selecting excipients that promote mucosal retention, minimal irritation, and preservative compatibility. 
• Ensuring dose uniformity through the device (shake-before-use validation, spray pattern testing). 

These formulations are developed and tested to meet regulatory standards for non-sterile nasal/otic use, with validated microbial control systems.

We tailor viscosity and density to balance ease of pouring with suspension stability throughout the drug product’s shelf life.

Topical suspensions play a vital role in dermatologic and mucosal applications, when the API crystalline form, solubility profile, or penetration characteristics require a solid-in-liquid format. In these formulations, we help clients:

• Maintain physical stability of APIs that tend to aggregate or crystallize. 
• Ensure even distribution of active particles throughout the product. 
• Select and test film-forming agents, emollients, or penetration enhancers as needed. 
• Evaluate in vitro release and particle mobility to optimize drug delivery performance. 

Packaging compatibility (such as bottles with agitation balls or specialized applicators) is evaluated early in development to ensure proper dosing, product stability, and user experience.